The Nef Protein of Human Immunodeficiency Virus is a Broad-Spectrum Modulator of Chemokine Receptor Cell Surface Levels That Acts Independently of Classical Motifs for Receptor Endocytosis and Gαi-Signaling
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چکیده
Abbreviations used: HIV, human immunodeficiency virus ; SIV, simian immunodeficiency virus; Env, envelope glycoprotein, VSV-G, vesicular stomatitis virus glycoprotein; GPCR, G-protein coupled receptor; CKR, chemokine receptor, PTX, Bordetella pertussis toxin; SH3, src homology-3; PACS-1, phosphofurin acidic cluster sorting protein-1; MHC, major histocompatibility class; GFP, green fluorescent protein; RFP, monomeric red fluorescent protein; IRES, internal ribosome entry site; AP-1/2/3, adaptin-1/2/3; FBS, fetal bovine serum
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